Attenuated strain of M. bovis used in the Bacillus Calmette-Guérin vaccine
Karlson & Lessel 1970, ATCC 19210
- See: Tuberculosis
Mycobacterium bovis is a slow-growing (16 to 20 hour generation time), aerobic bacterium and the causative agent of tuberculosis in cattle (known as bovine TB). Related to M. tuberculosis—the bacteria which causes tuberculosis in humans—M. bovis can also jump the species barrier and cause tuberculosis in humans.
It has been estimated that, during the first half of the 20th century, M. bovis was responsible for more losses among farm animals than all other infectious diseases combined. Infection occurs if the bacterium is ingested.
M. bovis is usually transmitted to humans via infected milk, although it can also spread via aerosol droplets. Actual infections in humans are rare, mostly due to pasteurisation killing any bacteria in infected milk; as well, cattle are randomly tested for the disease and immediately destroyed if infected. However, in areas of the developing world where pasteurisation is not routine, M. bovis is a relatively common cause of human tuberculosis.
In the 1930s, 40% of cows in the UK were infected with M. bovis and there were 50,000 new cases of human M. bovis infection every year. Since 1990, only one case of human M. bovis infection acquired from an animal source has been documented in the UK. In 2004, 5.6% of herds were affected by restrictions because of M. bovis infection.
Badgers (Meles meles) were first identified as carriers of M. bovis 30 years ago, but it was the report of an independent review committee in 1997 which concluded that badgers made an important contribution to the spread of M. bovis between herds of cattle. This was the major cause of the current battle between animal conservationists (keen to save the badger) and farmers (keen to cull badgers, to reduce livestock losses). The Randomised Badger Culling Trial  (designed, overseen and analysed by the Independent Scientific Group on Cattle TB, or ISG ) was a large field trial of widescale (proactive) culling and localised reactive culling (in comparison with areas which received no badger culling). In their final report , the ISG concluded: "First, while badgers are clearly a source of cattle TB, careful evaluation of our own and others’ data indicates that badger culling can make no meaningful contribution to cattle TB control in Britain. Indeed, some policies under consideration are likely to make matters worse rather than better. Second, weaknesses in cattle testing regimes mean that cattle themselves contribute significantly to the persistence and spread of disease in all areas where TB occurs, and in some parts of Britain are likely to be the main source of infection. Scientific findings indicate that the rising incidence of disease can be reversed, and geographical spread contained, by the rigid application of cattle-based control measures alone." On 26 July 2007, the Minister of State, Department for Environment, Food and Rural Affairs (Lord Rooker) said "My Lords, we welcome the Independent Scientific Group’s final report, which further improves the evidence base. We are carefully considering the issues that the report raises, and will continue to work with industry, government advisers and scientific experts in reaching policy decisions on these issues."
In the UK many other mammals have been found to be infected with M. bovis but the frequency of isolation is much less than cattle and badgers. The disease is found in cattle throughout the globe but some countries have been able to reduce or limit the incidence of the disease through process of 'test and cull' of the cattle stock. Most of Europe and several Caribbean countries (including Cuba) are virtually free of M bovis. Australia is officially free of the disease since the successful BTEC program, but residual infections might exist in feral water buffalo in isolated parts of the Northern Territory. In the United States, there is endemic M. bovis in White-tailed Deer in the northeastern portion of the state of Michigan and in northern Minnesota and sporadic import of the disease from Mexico. In Canada, there are affected wild elk and white-tailed deer around Ridning Mountiain National Park in Manitoba. The disease has also been found in wild buffalo in South Africa and Brush-tailed possums in New Zealand.
- Note: Is intrinsically resistant to Pyrazinamide (PZA). The treatment of M. bovis is extrapolated from experience with the treatment of PZA-resistant M. tuberculosis
- 1. Pulmonary and most extrapulmonary disease
- Grange, John M. (1996). "Guidelines for speciation within the Mycobacterium tuberculosis complex. Second edition" (PDF). World Health Organization. Retrieved 2007-08-02. Unknown parameter
- O'Reilly LM, Daborn CJ. (1995). "The epidemiology of Mycobacterium bovis infections in animals and man: a review". Tuber Lung Dis. 76 (Suppl 1): 1–46. PMID 7579326. Unknown parameter
- Reynolds D (2006). "A review of tuberculosis science and policy in Great Britain". Vet Microbiol. 112: 119–126. PMID 16343818. Text " CrossRef" ignored (help)
- Krebs JR, Anderson T, Clutton-Brock WT; et al. (1997). Bovine tuberculosis in cattle and badgers: an independent scientific review. London: Ministry of Agriculture, Fisheries and Food.
- defra. "Bovine TB: Randomised Badger Culling Trial (RBCT)". Retrieved 2007-07-30.
- defra. "Bovine TB: The Independent Scientific Group on Cattle TB". Retrieved 2007-07-30.
- Independent Scientific Group on Cattle TB. "Bovine TB: The Scientific Evidence; Final Report of the Independent Scientific Group on Cattle TB Presented to the Secretary of State for Environment, Food and Rural Affairs The Rt Hon David Miliband MP, June 2007" (PDF). Retrieved 2007-07-30.
- Daily Hansard. "Daily Hansard, House of Lords; Thursday, 26 July 2007". Retrieved 2007-07-30.
- Debora MacKenzie. "TB travelled from a farm to a night club". Retrieved 2007-03-21.
- Griffith AS and Munro WT (1944). "Human pulmonary tuberculosis of bovine
origin in Great Britain". J Hyg. 43: 229–40. line feed character in
|title=at position 40 (help)
- Tice FJ (1944). "Man, a source of bovine tuberculosis in cattle". Cornell Vet. 34: 363–5.
- American Thoracic Society. CDC. Infectious Diseases Society of America (2003). "Treatment of tuberculosis". MMWR Recomm Rep. 52 (RR-11): 1–77. PMID 12836625.
Cost Effectiveness of Mycobacterium bovis
| group5 = Clinical Trials Involving Mycobacterium bovis | list5 = Ongoing Trials on Mycobacterium bovis at Clinical Trials.gov • Trial results on Mycobacterium bovis • Clinical Trials on Mycobacterium bovis at Google
| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Mycobacterium bovis | list6 = US National Guidelines Clearinghouse on Mycobacterium bovis • NICE Guidance on Mycobacterium bovis • NHS PRODIGY Guidance • FDA on Mycobacterium bovis • CDC on Mycobacterium bovis
| group7 = Textbook Information on Mycobacterium bovis | list7 = Books and Textbook Information on Mycobacterium bovis
| group8 = Pharmacology Resources on Mycobacterium bovis | list8 = AND (Dose)}} Dosing of Mycobacterium bovis • AND (drug interactions)}} Drug interactions with Mycobacterium bovis • AND (side effects)}} Side effects of Mycobacterium bovis • AND (Allergy)}} Allergic reactions to Mycobacterium bovis • AND (overdose)}} Overdose information on Mycobacterium bovis • AND (carcinogenicity)}} Carcinogenicity information on Mycobacterium bovis • AND (pregnancy)}} Mycobacterium bovis in pregnancy • AND (pharmacokinetics)}} Pharmacokinetics of Mycobacterium bovis •
| group9 = Genetics, Pharmacogenomics, and Proteinomics of Mycobacterium bovis | list9 = AND (pharmacogenomics)}} Genetics of Mycobacterium bovis • AND (pharmacogenomics)}} Pharmacogenomics of Mycobacterium bovis • AND (proteomics)}} Proteomics of Mycobacterium bovis
| group11 = Commentary on Mycobacterium bovis | list11 = Blogs on Mycobacterium bovis
| group12 = Patient Resources on Mycobacterium bovis | list12 = Patient resources on Mycobacterium bovis • Discussion groups on Mycobacterium bovis • Patient Handouts on Mycobacterium bovis • Directions to Hospitals Treating Mycobacterium bovis • Risk calculators and risk factors for Mycobacterium bovis
| group13 = Healthcare Provider Resources on Mycobacterium bovis | list13 = Symptoms of Mycobacterium bovis • Causes & Risk Factors for Mycobacterium bovis • Diagnostic studies for Mycobacterium bovis • Treatment of Mycobacterium bovis
| group14 = Continuing Medical Education (CME) Programs on Mycobacterium bovis | list14 = CME Programs on Mycobacterium bovis
| group17 = Informatics Resources on Mycobacterium bovis | list17 = List of terms related to Mycobacterium bovis