Mucoepidermoid carcinoma surgery

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Badria Munir M.B.B.S.[2] , Maria Fernanda Villarreal, M.D. [3]

Overview

Surgery is the mainstay of therapy for mucoepidermoid carcinoma.

Surgery

  • Mucoepidermoid carcinoma (low-grade): complete surgical excision with sparing of the facial nerve.[1][1]
  • Mucoepidermoid carcinoma (high-grade): parotidectomy with facial nerve sparing may be followed by radiotherapy.
  • Clinically aggressive mucoepidermoid carcinoma tumors with facial nerve involvement will require radical surgery with sacrifice of the facial nerve and radiotherapy. [2]
  • Primary nerve grafting using the sural nerve if possible is performed.
  • Lymph node dissection is usually only performed for detected nodal metastasis.
  • Low grade mucoepidermoid carcinoma in the floor of the mouth can be surgically excised along with involved lymph node.[3][4]
  • When the tumor is at an inaccessible location, clinical trial therapies (especially for stage IV disease) including:
    • Therapeutic drugs
    • Radiation
    • Stem cell transplantation
    • Monoclonal antibodies
  • Either singly or in combination of various therapies
  • Follow-up care with regular screening and check-ups are important[5]

Indications

  • Indications for surgery for mucoepidermoid carcinoma, include:[6]
  • Biological and histological features suitable for surgery

Gallery

References

  1. 1.0 1.1 Mucoepidermoid Carcinoma Surgery. WikiBooks. https://en.wikibooks.org/wiki/Radiation_Oncology/Head_%26_Neck/Salivary_gland Accessed on February 17,2016
  2. Gedar Totuk OM, Demir MK, Yapicier O, Mestanoglu M (2017). "Low-Grade Mucoepidermoid Carcinoma of the Lacrimal Gland in a Teenaged Patient". Case Rep Ophthalmol Med. 2017: 2418505. doi:10.1155/2017/2418505. PMC 5727657. PMID 29318070.
  3. Rinaldo A, Shaha AR, Pellitteri PK, Bradley PJ, Ferlito A (January 2004). "Management of malignant sublingual salivary gland tumors". Oral Oncol. 40 (1): 2–5. PMID 14662408.
  4. Helmus C (August 1997). "Subtotal parotidectomy: a 10-year review (1985 to 1994)". Laryngoscope. 107 (8): 1024–7. PMID 9261001.
  5. Maloth AK, Nandan SR, Kulkarni PG, Dorankula SP, Muddana K (December 2015). "Mucoepidermoid Carcinoma of Floor of the Mouth - A Rarity". J Clin Diagn Res. 9 (12): ZD03–4. doi:10.7860/JCDR/2015/15595.6912. PMC 4717804. PMID 26813873.
  6. Rapidis, Alexander D.; Givalos, Nikolaos; Gakiopoulou, Hariklia; Stavrianos, Spyros D.; Faratzis, Gregory; Lagogiannis, George A.; Katsilieris, Ioannis; Patsouris, Efstratios (2007). "Mucoepidermoid carcinoma of the salivary glands". Oral Oncology. 43 (2): 130–136. doi:10.1016/j.oraloncology.2006.03.001. ISSN 1368-8375.

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