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Monotherapy refers to a therapy which is taken by itself. It can be applied to any therapeutic approach, but it is most commonly used to describe the use of a single medication. Normally, monotherapy is selected because a single medication is adequate to treat the medical condition. However, monotherapies may also be used because of unwanted side effects or dangerous drug interactions.[1]

Monotherapy is rarely used in treating some conditions, such as HIV infection and many kinds of cancer.

The opposite of monotherapy is polytherapy.

See also

  • Polypill, a medication which contains a combination of active ingredients


  1. "Glossary" (HTML). Retrieved 2008-04-02. Monotherapy: The treatment of epilepsy with a single medication rather than a combination. Monotherapy has distinct advantages over polytherapy in many patients, including absence of drug-drug interactions, fewer side effects, simpler dosing, and lower cost. However, not all patients can be controlled with monotherapy.