Monoblast

Jump to: navigation, search
Monoblast

WikiDoc Resources for Monoblast

Articles

Most recent articles on Monoblast

Most cited articles on Monoblast

Review articles on Monoblast

Articles on Monoblast in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Monoblast

Images of Monoblast

Photos of Monoblast

Podcasts & MP3s on Monoblast

Videos on Monoblast

Evidence Based Medicine

Cochrane Collaboration on Monoblast

Bandolier on Monoblast

TRIP on Monoblast

Clinical Trials

Ongoing Trials on Monoblast at Clinical Trials.gov

Trial results on Monoblast

Clinical Trials on Monoblast at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Monoblast

NICE Guidance on Monoblast

NHS PRODIGY Guidance

FDA on Monoblast

CDC on Monoblast

Books

Books on Monoblast

News

Monoblast in the news

Be alerted to news on Monoblast

News trends on Monoblast

Commentary

Blogs on Monoblast

Definitions

Definitions of Monoblast

Patient Resources / Community

Patient resources on Monoblast

Discussion groups on Monoblast

Patient Handouts on Monoblast

Directions to Hospitals Treating Monoblast

Risk calculators and risk factors for Monoblast

Healthcare Provider Resources

Symptoms of Monoblast

Causes & Risk Factors for Monoblast

Diagnostic studies for Monoblast

Treatment of Monoblast

Continuing Medical Education (CME)

CME Programs on Monoblast

International

Monoblast en Espanol

Monoblast en Francais

Business

Monoblast in the Marketplace

Patents on Monoblast

Experimental / Informatics

List of terms related to Monoblast

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Monoblasts are normally found in bone marrow and do not appear in the normal peripheral blood. They mature into monocytes which in turn develop into macrophages.

Structure

A typical monoblast is about 12 to 20 µm in diameter, has a nuclear to cytoplasm ration of 4:1 to 3:1, and, like most myeloid blasts, has a round to oval nucleus with fine chromatin structure. One to four nucleoli are usually visible. The nucleus can be central or eccentric and it can show evidence of indentation or folding. The cytoplasm is agranular, stains moderately to lightly basophilic, and often has an intensely stained periphery and a prominent perinuclear zone.

Maturation

The monoblast is the first stage of monocyte-macrophage maturation. The developmental stages of the monoblast are: CFU-GM (pluripotential hemopoietic stem cell or hemocytoblast) -> monoblast -> promonocyte -> monocyte-> macrophage.

Additional images

See also



Linked-in.jpg