There are several different monoamine transporters:
- The dopamine transporter, DAT.
- The norepinephrine transporter, NET.
- The serotonin transporter, SERT.
DAT, NET and SERT are related to each other and they all consist of a structure of 12 transmembrane helices.
Modern antidepressants typically work by enhancing serotonergic, noradrenergic or dopaminergic neurotransmission by binding to the corresponding transporter, and thereby inhibiting neurotransmitter reuptake and raising active levels in the synapse. Examples include fluoxetine, a selective serotonin reuptake inhibitor; reboxetine, a norepinephrine reuptake inhibitor and bupropion, which inhibits both the norepinephrine and dopamine transporter.
G.E. Torres, R.R. Gainetdinov and M.G. Caron (2003). "Plasma membrane monoamine transporters: structure, regulation and function". Nat. Rev. Neurosci. 4 (1): 13–25. PMID 12511858. (Review)