Mirfentanil

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Template:Chembox E number
Mirfentanil
IUPAC name N-[1-(2-phenylethyl)piperidin-4-yl]-

N-pyrazin-2-ylfuran-2-carboxamide

Other names MS-32, NIH-10647
Identifiers
3D model (JSmol)
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Properties
C22H24N4O2
Molar mass 376.45156 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

Mirfentanil is a fentanyl derivative with strong selectivity for the μ opioid receptor. At lower doses, it antagonizes the analgesic effects of alfentanil and substitutes for naloxone in morphine-treated monkeys; however, it also reverses naloxone-precipitated withdrawal in pigeons trained to discriminate morphine from naloxone.[1]

At high doses, it exhibits analgesic activity which is not fully reversed by opioid antagonists, suggesting that the drug has both opioid and non-opioid mechanisms of action.[1][2]

References

  1. 1.0 1.1 France CP, Winger G, Medzihradsky F, Seggel MR, Rice KC, Woods JH. "Mirfentanil: pharmacological profile of a novel fentanyl derivative with opioid and nonopioid effects." Journal of Pharmacology and Experimental Therapeutics. 1991 Aug;258(2):502-10. PMID 1650830
  2. Carr DJ, Brockunier LL, Scott M, Bagley JR, France CP. "Mirfentanil antagonizes morphine-induced suppression of splenic NK activity in mice." Immunopharmacology. 1996 Aug; 34 (1): 9-16. PMID 8880221

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