Methylscopolamine

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Methylscopolamine
Systematic (IUPAC) name
(1R,2S,4R,5S,7R)-{[(2R)-3-hydroxy-2-phenylpropanoyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane
Identifiers
CAS number 155-41-9
ATC code A03BB03 S01FA03
PubChem 441342
DrugBank DB00462
Chemical data
Formula C18H24NO4 
Mol. mass 318.388 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 3–4 hrs
Excretion  ?
Therapeutic considerations
Pregnancy cat.

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Legal status
Routes  ?

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Methylscopolamine or methscopolamine, usually provided as the bromide salt (trade name Pamine), is an oral medication used along with other medications to treat peptic ulcers by reducing stomach acid secretion.[1] Proton pump inhibitors and antihistamine medications have made this use obsolete. It can also be used for stomach or intestinal spasms, to reduce salivation, and to treat motion sickness. Methscopolamine is also commonly used as a drying agent, to dry up post-nasal drip, in cold, irritable bowel syndrome and allergy medications (trade names Extendryl, AlleRx, Rescon).

Methscopolamine, a methylated derivative of scopolamine, is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine. Its mechanism of action involves blocking the muscarinic acetylcholine receptors.

References

  1. Drugs.com: Methscopolamine
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