Methylaspartate mutase

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In enzymology, a methylaspartate mutase (EC 5.4.99.1) is an enzyme that catalyzes the chemical reaction

L-threo-3-methylaspartate L-glutamate

Hence, this enzyme has one substrate, L-threo-3-methylaspartate, and one product, L-glutamate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is L-threo-3-methylaspartate carboxy-aminomethylmutase. Other names in common use include glutamate mutase, glutamic mutase, glutamic isomerase, glutamic acid mutase, glutamic acid isomerase, methylaspartic acid mutase, beta-methylaspartate-glutamate mutase, and glutamate isomerase. This enzyme participates in c5-branched dibasic acid metabolism. It employs one cofactor, cobamide.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1B1A, 1BE1, 1CB7, 1CCW, 1FMF, 1I9C, 1ID8, and 2PWH.

References

  • IUBMB entry for 5.4.99.1
  • BRENDA references for 5.4.99.1 (Recommended.)
  • PubMed references for 5.4.99.1
  • PubMed Central references for 5.4.99.1
  • Google Scholar references for 5.4.99.1
  • BARKER HA, ROOZE V, SUZUKI F, IODICE AA (1964). "THE GLUTAMATE MUTASE SYSTEM. ASSAYS AND PROPERTIES". J. Biol. Chem. 239: 3260&ndash, 6. PMID 14245371.
  • Weissbach H, Toohey J and Barker HA (1959). "Isolation and properties of B12 coenzymes containing benzimidazole or dimethylbenzimidazole". Proc. Natl. Acad. Sci. USA. 45: 521&ndash, 528.

External links

The CAS registry number for this enzyme class is 9032-97-7.

Gene Ontology (GO) codes


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