Methyl-coenzyme M reductase

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Methyl-coenzyme M reductase (MCR) is an enzyme that occurs in archaea and catalyzes the formation of methane by combining the hydrogen donor coenzyme B and the methyl donor coenzyme M. The enzyme has two active sites, each occupied by the nickel-containing F430 cofactor.[1] This conversion is symbolically written as:

CH3-S-CoM + HS-CoB → CH4 + CoB-S-S-CoM


  1. Thauer, R. K., "Biochemistry of methanogenesis: a tribute to Marjory Stephenson", Microbiology, 1998, 144, 2377-2406. PMID 9782487