Mesial temporal sclerosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Mesial temporal sclerosis is a specific pattern of hippocampal neuron cell loss[1] [2]. There are 3 specific patterns of cell loss; Cell loss might involve sectors CA1 and CA4, CA4 alone, or CA1 to CA4 [3]. Associated hippocampal atrophy and gliosis is common[4]. MRI scan commonly displays increased T2 signal and hippocampal atrophy [5] Mesial temporal sclerosis might occur with other temporal lobe abnormalities (dual pathology) [6]. Mesial temporal sclerosis is the most common pathological abnormality in temporal lobe epilepsy[7] [8].

Patient #1: Asymmetry of the mesial temporal lobes is consistent with left mesial temporal sclerosis

Related Chapters

References

  1. Bronen RA, Fulbright RK, Spencer DD, et al. 1997
  2. Trepeta, Scott 2007
  3. Trepeta, Scott 2007
  4. Bronen RA, Fulbright RK, Spencer DD, et al. 1997
  5. Bronen RA, Fulbright RK, Spencer DD, et al. 1997
  6. Bronen RA, Fulbright RK, Spencer DD, et al. 1997
  7. Bronen RA, Fulbright RK, Spencer DD, et al. 1997
  8. Trepeta, Scott 2007


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