Melanotransferrin

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Template:Infobox gene Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).


The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.[1] It is part of neural crest tissue, often present in melanotic neuroectodermal tumor of infancy.


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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