Jump to: navigation, search
ICD-10 Q04.5
ICD-9 742.4
OMIM 155350
DiseasesDB 22519

WikiDoc Resources for Megalencephaly


Most recent articles on Megalencephaly

Most cited articles on Megalencephaly

Review articles on Megalencephaly

Articles on Megalencephaly in N Eng J Med, Lancet, BMJ


Powerpoint slides on Megalencephaly

Images of Megalencephaly

Photos of Megalencephaly

Podcasts & MP3s on Megalencephaly

Videos on Megalencephaly

Evidence Based Medicine

Cochrane Collaboration on Megalencephaly

Bandolier on Megalencephaly

TRIP on Megalencephaly

Clinical Trials

Ongoing Trials on Megalencephaly at Clinical

Trial results on Megalencephaly

Clinical Trials on Megalencephaly at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Megalencephaly

NICE Guidance on Megalencephaly


FDA on Megalencephaly

CDC on Megalencephaly


Books on Megalencephaly


Megalencephaly in the news

Be alerted to news on Megalencephaly

News trends on Megalencephaly


Blogs on Megalencephaly


Definitions of Megalencephaly

Patient Resources / Community

Patient resources on Megalencephaly

Discussion groups on Megalencephaly

Patient Handouts on Megalencephaly

Directions to Hospitals Treating Megalencephaly

Risk calculators and risk factors for Megalencephaly

Healthcare Provider Resources

Symptoms of Megalencephaly

Causes & Risk Factors for Megalencephaly

Diagnostic studies for Megalencephaly

Treatment of Megalencephaly

Continuing Medical Education (CME)

CME Programs on Megalencephaly


Megalencephaly en Espanol

Megalencephaly en Francais


Megalencephaly in the Marketplace

Patents on Megalencephaly

Experimental / Informatics

List of terms related to Megalencephaly


Megalencephaly is a type of cephalic disorder. Also called macrencephaly, this is a condition in which there is an abnormally large, heavy, and usually malfunctioning brain. By definition, the brain weight is greater than average for the age and sex of the infant or child. Head enlargement may be evident at birth or the head may become abnormally large in the early years of life.

Symptoms of megalencephaly may include delayed development, convulsive disorders, corticospinal (brain cortex and spinal cord) dysfunction, and seizures. Megalencephaly affects males more often than females.

The prognosis for individuals with megalencephaly largely depends on the underlying cause and the associated neurological disorders. Treatment is symptomatic. Megalencephaly may lead to a condition called macrocephaly. Unilateral megalencephaly or hemimegalencephaly is a rare condition characterized by the enlargement of one-half of the brain. Children with this disorder may have a large, sometimes asymmetrical head. Often they suffer from intractable seizures and mental retardation. The prognosis for those with hemimegalencephaly is poor.

The prognosis for hemimegalencephaly ranges from poor to highly functioning. In some cases, children with hemimegalencephaly are severely mentally retarded and must undergo a hemispherectomy to stop seizure activity. In others, seizure activity can be controlled by medication; and the affected child develops mentally and physically trailing normal development by 1-2 years.

External links