Meclofenamic acid

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Meclofenamic acid
Meclofenamic acid.png
Clinical data
Trade namesMeclomen
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E number{{#property:P628}}
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Chemical and physical data
FormulaC14H11Cl2NO2
Molar mass296.14864 g/mol

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Meclofenamic acid (brand Meclomen) is a drug used for joint, muscular pain, arthritis and dysmenorrhea.[1] It is a member of the NSAID class of drugs and was approved by the FDA in 1980. It inhibits the synthesis of prostaglandins.[2]

Use in horses

Meclofenamic acid is sold under the trade name "Arquel" for use in horses, and is administered as an oral granual form at a dose of 2.2 mg/kg/day.[3] It has a relatively slow onset of action, taking 36-48 hours for full effect,[4] and is most useful for treatment of chronic musculoskeletal disease.[5] It has been found to be beneficial for the treatment of navicular syndrome, laminitis, and osteoarthritis,[4] in some cases having a more profound effect than the commonly-used NSAID phenylbutazone.[6] However, due to cost, it is not routinely used in practice. Toxicity due to excessive dosage is similar to that of phenylbutazone, including depression, anorexia, weight loss, edema, diarrhea, oral ulceration, and decreased hematocrit.[6]

References

  1. http://www.medicinenet.com/meclofenamate/article.htm
  2. Syed MM, Parekh AB, Tomita T (December 1990). "Receptors involved in mechanical responses to catecholamines in the circular muscle of guinea-pig stomach treated with meclofenamate". British Journal of Pharmacology. 101 (4): 809–14. doi:10.1111/j.1476-5381.1990.tb14162.x. PMC 1917864. PMID 1982230.
  3. McIlwraith CW, Frisbie DD, Kawcak CE. Nonsteroidal Anti-Inflammatory Drugs. Proc. AAEP 2001 (47): 182-187.
  4. 4.0 4.1 Cotter GH, Riley WF, Beck CC, Coppock RW. Arquel (Cl- 1583). A new nonsteroidal anti-inflammatory drug for horses, in Proceedings. Am Assoc Equine Practnr 1973;19: 81–90.
  5. Snow DH, Baxter P, Whiting B. The pharmacokinetics of meclofenamic acid in the horse. J Vet Pharmacol Ther 1981; 4:147–156.
  6. 6.0 6.1 Lees P, Higgins AJ. Clinical pharmacology in therapeutic uses of non-steroidal anti-inflammatory drugs in the horse. Equine Vet J 1985;17:83–96.

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