May Hegglin anomaly

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May Hegglin anomaly
ICD-10 D72.0
ICD-9 288.2
OMIM 155100
DiseasesDB 29517
eMedicine ped/1383 

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


May Hegglin's anomaly, as it is also known, is a rare genetic disorder of the blood platelets that causes them to be abnormally large. Also, this anomaly causes abnormalities in the white blood cells known as leukocytes.

Presentation

In the leukocytes, the presence of very small rods (around 3 micrometers), or Dohle bodies can be seen in the cytoplasm.

Treatment

In many cases, May Hegglin's requires no treatment. However, in extreme cases, blood platelet transfusions may be necessary

Causes

An association with MYH9 has been described.[1]

References

  1. Saito H, Kunishima S (2007). "Historical hematology: May-Hegglin anomaly". Am J Hematol. PMID 17975807. doi:10.1002/ajh.21102. 

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