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Serpin peptidase inhibitor, clade B (ovalbumin), member 5
PBB Protein SERPINB5 image.jpg
PDB rendering based on 1wz9.
Symbol(s) SERPINB5; PI5; maspin
External IDs OMIM: 154790 MGI109579 Homologene20580
RNA expression pattern

PBB GE SERPINB5 204855 at tn.png

More reference expression data

Human Mouse
Entrez 5268 20724
Ensembl ENSG00000206075 ENSMUSG00000067006
Uniprot P36952 Q3ULZ0
Refseq NM_002639 (mRNA)
NP_002630 (protein)
NM_009257 (mRNA)
NP_033283 (protein)
Location Chr 18: 59.3 - 59.32 Mb Chr 1: 108.69 - 108.71 Mb
Pubmed search [1] [2]

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]

Maspin is a serpin and tumor suppressor gene.[1]


  1. Sager R, Sheng S, Pemberton P, Hendrix M. "Maspin. A tumor suppressing serpin". Adv Exp Med Biol. 425: 77–88. PMID 9433491. 

Further reading

  • Sager R, Sheng S, Pemberton P, Hendrix MJ (1998). "Maspin. A tumor suppressing serpin.". Adv. Exp. Med. Biol. 425: 77–88. PMID 9433491. 
  • Sheng S (2006). "The promise and challenge toward the clinical application of maspin in cancer.". Front. Biosci. 9: 2733–45. PMID 15353310. 
  • Lockett J, Yin S, Li X; et al. (2006). "Tumor suppressive maspin and epithelial homeostasis.". J. Cell. Biochem. 97 (4): 651–60. PMID 16329135. doi:10.1002/jcb.20721. 
  • Chen EI, Yates JR (2006). "Maspin and tumor metastasis.". IUBMB Life. 58 (1): 25–9. PMID 16540429. doi:10.1080/15216540500531721. 
  • Khalkhali-Ellis Z (2007). "Maspin: the new frontier.". Clin. Cancer Res. 12 (24): 7279–83. PMID 17189399. doi:10.1158/1078-0432.CCR-06-1589. 
  • Schneider SS, Schick C, Fish KE; et al. (1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene.". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3147–51. PMID 7724531. 
  • Pemberton PA, Wong DT, Gibson HL; et al. (1995). "The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin.". J. Biol. Chem. 270 (26): 15832–7. PMID 7797587. 
  • Zou Z, Anisowicz A, Hendrix MJ; et al. (1994). "Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells.". Science. 263 (5146): 526–9. PMID 8290962. 
  • Pemberton PA, Tipton AR, Pavloff N; et al. (1998). "Maspin is an intracellular serpin that partitions into secretory vesicles and is present at the cell surface.". J. Histochem. Cytochem. 45 (12): 1697–706. PMID 9389773. 
  • Xia W, Lau YK, Hu MC; et al. (2000). "High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma.". Oncogene. 19 (20): 2398–403. PMID 10828881. doi:10.1038/sj.onc.1203535. 
  • Biliran H, Sheng S (2002). "Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin.". Cancer Res. 61 (24): 8676–82. PMID 11751384. 
  • Blacque OE, Worrall DM (2002). "Evidence for a direct interaction between the tumor suppressor serpin, maspin, and types I and III collagen.". J. Biol. Chem. 277 (13): 10783–8. PMID 11788595. doi:10.1074/jbc.M110992200. 
  • Dokras A, Gardner LM, Kirschmann DA; et al. (2002). "The tumour suppressor gene maspin is differentially regulated in cytotrophoblasts during human placental development.". Placenta. 23 (4): 274–80. PMID 11969337. doi:10.1053/plac.2001.0784. 
  • Jiang N, Meng Y, Zhang S; et al. (2002). "Maspin sensitizes breast carcinoma cells to induced apoptosis.". Oncogene. 21 (26): 4089–98. PMID 12037665. doi:10.1038/sj.onc.1205507. 
  • Odero-Marah VA, Khalkhali-Ellis Z, Schneider GB; et al. (2002). "Tyrosine phosphorylation of maspin in normal mammary epithelia and breast cancer cells.". Biochem. Biophys. Res. Commun. 295 (4): 800–5. PMID 12127964. 
  • Maass N, Biallek M, Rösel F; et al. (2002). "Hypermethylation and histone deacetylation lead to silencing of the maspin gene in human breast cancer.". Biochem. Biophys. Res. Commun. 297 (1): 125–8. PMID 12220518. 
  • Sood AK, Fletcher MS, Gruman LM; et al. (2002). "The paradoxical expression of maspin in ovarian carcinoma.". Clin. Cancer Res. 8 (9): 2924–32. PMID 12231537. 
  • Son HJ, Sohn TS, Song SY; et al. (2003). "Maspin expression in human gastric adenocarcinoma.". Pathol. Int. 52 (8): 508–13. PMID 12366809. 
  • Bass R, Fernández AM, Ellis V (2003). "Maspin inhibits cell migration in the absence of protease inhibitory activity.". J. Biol. Chem. 277 (49): 46845–8. PMID 12384513. doi:10.1074/jbc.C200532200. 

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