Masoprocol

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Masoprocol
Systematic (IUPAC) name
4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
Identifiers
CAS number 500-38-9
ATC code L01XX10
PubChem 71398
DrugBank DB00179
Chemical data
Formula C18H22O4 
Mol. mass 302.365 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability Very low
Metabolism ?
Half life ?
Excretion ?
Therapeutic considerations
Pregnancy cat.

B(US)

Legal status
Routes Topical

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.

Also called nordihydroguaiaretic acid, NDGA, and actinex.

Mechanism

Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

It is a lipoxygenase inhibitor.[1]

References

  1. "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". Am. J. Physiol. Endocrinol. Metab. 279 (3): E593–600. September 2000. PMID 10950827. 

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