Magnesium oxide

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Magnesium oxide
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rabin Bista, M.B.B.S. [2]

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Overview

Magnesium oxide is a antacid that is FDA approved for the treatment of acid indigestion, upset stomach. Common adverse reactions include diarrhea, allergic reaction.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

Directions

  • Antacid Directions: (take 1 tablet twice a day or as directed by a physician
  • Magnesium Supplement Directions: (take 1 to 2 tablets daily or as directed by a physician

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Magnesium oxide in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Magnesium oxide in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

  • Safety and efficacy in pediatrics patients has not been established.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Magnesium oxide in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Magnesium oxide in pediatric patients.

Contraindications

There is limited information regarding Magnesium oxide Contraindications in the drug label.

Warnings

  • Do Not Use
  • Do not take more than 2 tablets in a 24 hour period or use the maximum dosage of this product for more than two weeks, except under the advice and supervision of a physician. May have a laxative effect.
  • Ask a Doctor if you have:
  • Kidney disease
  • Ask a Doctor/Pharmacist before use if you are:
  • Taking a prescription drug. Antacids may interact with certain prescription drugs.
  • Pregnancy or Breast Feeding
  • If pregnant or breast feeding, ask a health professional before use.
  • Keep Out of Reach of Children

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Magnesium oxide in the drug label.

Postmarketing Experience

Laxative adverse reaction

Drug Interactions

There is limited information regarding Magnesium oxide Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • If pregnant or breast feeding, ask a health professional before use.


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Magnesium oxide in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Magnesium oxide during labor and delivery.

Nursing Mothers

If pregnant or breast feeding, ask a health professional before use.

Pediatric Use

There is no FDA guidance on the use of Magnesium oxide with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Magnesium oxide with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Magnesium oxide with respect to specific gender populations.

Race

There is no FDA guidance on the use of Magnesium oxide with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Magnesium oxide in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Magnesium oxide in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Magnesium oxide in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Magnesium oxide in patients who are immunocompromised.

Administration and Monitoring

Administration

Monitoring

There is limited information regarding Monitoring of Magnesium oxide in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Magnesium oxide in the drug label.

Overdosage

There is limited information regarding Chronic Overdose of Magnesium oxide in the drug label.

Pharmacology

Magnesium oxide
Magnesium chemb.png
IUPAC name Magnesium oxide
Other names Magnesia
Periclase
Identifiers
CAS number 1309-48-4
PubChem 14792
EINECS number 215-171-9
RTECS number OM3850000
ATC code A02AA02,A06AD02, A12CC10
Properties
Molecular formula MgO
Molar mass 40.3044 g/mol
Appearance White powder
Odor Odorless
Density 3.58 g/cm3
Melting point

2852 °C, 3125 K, 5166 °F

Boiling point

3600 °C, 3873 K, 6512 °F

Solubility in water 0.00062 g/100 mL (0 °C)
0.0086 g/100 mL (30 °C)
Solubility Soluble in acid, ammonia
insoluble in alcohol
Band gap 7.8 eV[1]
Thermal conductivity 45–60 W·m−1·K−1[2]
Refractive index (nD) 1.7355
Dipole moment 6.2 ± 0.6 D
Structure
Crystal structure Halite (cubic), cF8
Space group Fm3m, No. 225
Lattice constant a = 4.212Å Å
Coordination
geometry
Octahedral (Mg2+); octahedral (O2−)
Thermochemistry
Std enthalpy of
formation
ΔfHo298
−601.8 kJ·mol−1[3]
Standard molar
entropy
So298
26.9 J·mol−1·K−1[3]
Standard molar
heat capacity
, cpo
37.8 J/mol K
Hazards
MSDS ICSC 0504
EU Index Not listed
Main hazards Metal fume fever, Irritant
NFPA 704

NFPA 704.svg

0
1
0
 
R-phrases R36, R37, R38
Flash point Non-flammable
U.S. Permissible
exposure limit (PEL)
TWA 15 mg/m3 (fume)[4]
Related Compounds
Other anions Magnesium sulfide
Other cations Beryllium oxide
Calcium oxide
Strontium oxide
Barium oxide
Related compounds Magnesium hydroxide
Magnesium nitride
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Mechanism of Action

Structure

  • ACTIVE INGREDIENTS
Magnesium Oxide 400mg (241.3mg elemental magnesium)
  • INACTIVE INGREDIENTS
Colloidal silicon dioxide, croscarmellose sodium, microcrystalline cellulose, stearic acid

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Magnesium oxide in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Magnesium oxide in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Magnesium oxide in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Magnesium oxide in the drug label.

How Supplied

  • do not use if imprinted safety seal under cap is broken or missing
  • Magnesium content per tablet: 240 mg

Storage

  • store at room temperature 59°-86° F (15°-30°C)

Images

Drug Images

Package and Label Display Panel

PRINCIPAL DISPLAY PANEL

This image is provided by the National Library of Medicine.

Ingredients and Appearance

This image is provided by the National Library of Medicine.

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Magnesium oxide in the drug label.

Precautions with Alcohol

  • Alcohol-Magnesium oxide interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

There is limited information regarding look alike drug names.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. Taurian, O.E.; Springborg, M.; Christensen, N.E. (1985). "Self-consistent electronic structures of MgO and SrO" (PDF). Solid State Communications. 55 (4): 351–5. Bibcode:1985SSCom..55..351T. doi:10.1016/0038-1098(85)90622-2. 
  2. Application of magnesium compounds to insulating heat-conductive fillers. konoshima.co.jp
  3. 3.0 3.1 Zumdahl, Steven S. (2009). Chemical Principles (6th ed.). Houghton Mifflin Company. p. A22. ISBN 0-618-94690-X. 
  4. "Magnesium oxide". 

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