Magaldrate

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Magaldrate
Systematic (IUPAC) name
Magnesium aluminate monohydrate
Identifiers
CAS number 1317-26-6
ATC code A02AD02
A02AF01 (combination with antiflatulents)
PubChem 6336542
Chemical data
Formula AlMg2(OH)7·H2O
Mol. mass 212.66 g/mol
Pharmacokinetic data
Bioavailability Negligible
Metabolism Nil
Half life ?
Excretion Fecal and renal
Therapeutic considerations
Pregnancy cat.

C

Legal status

OTC

Routes Oral

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Magaldrate (INN) is a common antacid drug that is used for the treatment of duodenal and gastric ulcers, esophagitis from gastroesophageal reflux.

Available forms

Magaldrate is available in the form of oral suspension or tablets.

Pharmacology

Magaldrate is a hydroxymagnesium aluminate complex that is converted rapidly in gastric acid to Mg(OH)2 and Al(OH)3, which are absorbed poorly and thus provide a sustained antacid effect.[1]

Interactions and adverse reactions

Magaldrate may negatively influence drugs like tetracyclines, benzodiazepines, and indomethacin. High doses or prolonged usage may lead to an increment of defecation and a reduction in feces consistence. In some cases it can alter the functionality of the gastrointestinal tract, occasionally provoking constipation or diarrhea.

Brand names

The drug is sold with the following brand names: Digecid Plus (Beximco Pharma, Bangladesh), Marlox Plus (Incepta pharma Bangladesh), Gastid (SK+F, Bangladesh), Novelta (Bangladesh), Gadral (Italy); Magaltop (Italy); Magralibi (Italy); Mylanta (Australia); Riopan (Argentina, Austria, Brazil, Egypt, Germany, Italy, Mexico, Belgium, Switzerland, Greece).

References

  1. Laurence L., Brunton. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12th ed. 


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