MUC5B

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Mucin 5B, oligomeric mucus/gel-forming
Identifiers
Symbols MUC5B ; MUC5; MUC9; MG1
External IDs OMIM: 600770 HomoloGene23659
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 727897
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| na


|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | XM_001126093 (mRNA)
XP_001126093 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |na (mRNA)
na (protein)

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| na
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Mucin 5B, oligomeric mucus/gel-forming, also known as MUC5B, is a human gene.[1]


References

  1. "Entrez Gene: MUC5B mucin 5B, oligomeric mucus/gel-forming".

Further reading

  • Zalewska A, Zwierz K, Zółkowski K, Gindzieński A (2002). "Structure and biosynthesis of human salivary mucins". Acta Biochim. Pol. 47 (4): 1067–79. PMID 11996097.
  • Douglas WH, Reeh ES, Ramasubbu N; et al. (1991). "Statherin: a major boundary lubricant of human saliva". Biochem. Biophys. Res. Commun. 180 (1): 91–7. PMID 1718282.
  • Meezaman D, Charles P, Daskal E; et al. (1994). "Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5)". J. Biol. Chem. 269 (17): 12932–9. PMID 7513696.
  • Dufosse J, Porchet N, Audie JP; et al. (1993). "Degenerate 87-base-pair tandem repeats create hydrophilic/hydrophobic alternating domains in human mucin peptides mapped to 11p15". Biochem. J. 293 ( Pt 2): 329–37. PMID 7916618.
  • Troxler RF, Offner GD, Zhang F; et al. (1996). "Molecular cloning of a novel high molecular weight mucin (MG1) from human sublingual gland". Biochem. Biophys. Res. Commun. 217 (3): 1112–9. doi:10.1006/bbrc.1995.2884. PMID 8554565.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
  • Desseyn JL, Guyonnet-Dupérat V, Porchet N; et al. (1997). "Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family". J. Biol. Chem. 272 (6): 3168–78. PMID 9013550.
  • Nielsen PA, Bennett EP, Wandall HH; et al. (1997). "Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B". Glycobiology. 7 (3): 413–9. PMID 9147051.
  • Keates AC, Nunes DP, Afdhal NH; et al. (1997). "Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B". Biochem. J. 324 ( Pt 1): 295–303. PMID 9164870.
  • Desseyn JL, Aubert JP, Van Seuningen I; et al. (1997). "Genomic organization of the 3' region of the human mucin gene MUC5B". J. Biol. Chem. 272 (27): 16873–83. PMID 9201995.
  • Offner GD, Nunes DP, Keates AC; et al. (1998). "The amino-terminal sequence of MUC5B contains conserved multifunctional D domains: implications for tissue-specific mucin functions". Biochem. Biophys. Res. Commun. 251 (1): 350–5. doi:10.1006/bbrc.1998.9469. PMID 9790959.
  • Desseyn JL, Buisine MP, Porchet N; et al. (1998). "Genomic organization of the human mucin gene MUC5B. cDNA and genomic sequences upstream of the large central exon". J. Biol. Chem. 273 (46): 30157–64. PMID 9804771.
  • Desseyn JL, Rousseau K, Laine A (1999). "Fifty-nine bp repeat polymorphism in the uncommon intron 36 of the human mucin gene MUC5B". Electrophoresis. 20 (3): 493–6. doi:10.1002/(SICI)1522-2683(19990301)20:3<493::AID-ELPS493>3.0.CO;2-7. PMID 10217161.
  • Iontcheva I, Oppenheim FG, Offner GD, Troxler RF (2000). "Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system". J. Dent. Res. 79 (2): 732–9. PMID 10728974.
  • Chen Y, Zhao YH, Di YP, Wu R (2002). "Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5'-flanking region". Am. J. Respir. Cell Mol. Biol. 25 (5): 542–53. PMID 11713095.
  • Thomsson KA, Prakobphol A, Leffler H; et al. (2002). "The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse". Glycobiology. 12 (1): 1–14. PMID 11825880.
  • Raynal BD, Hardingham TE, Thornton DJ, Sheehan JK (2002). "Concentrated solutions of salivary MUC5B mucin do not replicate the gel-forming properties of saliva". Biochem. J. 362 (Pt 2): 289–96. PMID 11853536.
  • Banderas-Tarabay JA, Zacarías-D'Oleire IG, Garduño-Estrada R; et al. (2003). "Electrophoretic analysis of whole saliva and prevalence of dental caries. A study in Mexican dental students". Arch. Med. Res. 33 (5): 499–505. PMID 12459324.
  • Raynal BD, Hardingham TE, Sheehan JK, Thornton DJ (2003). "Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus". J. Biol. Chem. 278 (31): 28703–10. doi:10.1074/jbc.M304632200. PMID 12756239.

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