Lymphotoxin

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lymphotoxin alpha (TNF superfamily, member 1)
Identifiers
SymbolLTA
Alt. symbolsTNFB
Entrez4049
HUGO6709
OMIM153440
RefSeqNM_000595
UniProtP01374
Other data
LocusChr. 6 p21.3
lymphotoxin beta (TNF superfamily, member 3)
Identifiers
SymbolLTB
Alt. symbolsTNFC
Entrez4050
HUGO6711
OMIM600978
RefSeqNM_002341
UniProtQ06643
Other data
LocusChr. 6 p21.3

Lymphotoxin (previously known as tumor necrosis factor-beta) is a lymphokine cytokine.

It is a protein that is produced by Th1 type T-cells and induces vascular endothelial cells to change their surface adhesion molecules to allow phagocytic cells to bind to them.[1] It is also known to be required for normal development of Peyer's patches.[2]

Lymphotoxin is homologous to Tumor Necrosis Factor beta, but secreted by T-cells. It is paracrine due to the small amounts produced. The effects are similar to TNF-alpha, but TNF-beta is also important for the development of lymphoid organs.

See also

References

  1. Parham, Peter (2005). "Chapter 6: T-cell mediated immunity". The immune system (2nd ed.). New York: Garland Science. p. 172. ISBN 0-8153-4093-1.
  2. Kumar. "Chapter 13 – Diseases of White Blood Cells, Lymph Nodes, Spleen, and Thymus". In Kumar. Robbins and Cotran Pathologic Basis of Disease, Professional Edition (8th ed.).

External links



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