Lead poisoning diagnostic study of choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aksiniya Stevasarova, M.D.

Overview

The best and the most accurate method to diagnose lead poisoning is directly measuring the venous blood lead levels.

Diagnostic Study of Choice

Study of choice

  • [{Blood Lead Levels] is the gold standard test for the diagnosis of lead poisoning. [1]
  • The following result of [[blood lead levels] is confirmatory of lead poisoning:
    • BLL >5mcg/dL [2]

The comparison of various diagnostic studies for [disease name]

Test Sensitivity Specificity
Blood Lead Levels 100% 100%

Blood Lead Levels= The best test based on the feature

Diagnostic results

The following result of direct venous blood lead levels in patients is confirmatory of lead poisoning:

  • BLL >5mcg/dL
  • BLL >40mcg/dL requires treatment with chelating agents
Sequence of Diagnostic Studies

The BLL test should be performed when:

  • The patient presented with symptoms like abdominal pain ("lead colic"), joint/muscle aches, short-term memory problems, difficulty concentrating, irritability, anemia and nephropathy is the first step of diagnosis.
  • A positive venous blood lead levels >5mcg is detected in the patient, to confirm the diagnosis.

The rest of the main laboratory tests that measure lead effects are:

Diagnostic Criteria

  • There are no established criteria for the diagnosis of lead poisoning. What matters in diagnosing lead poisoning is directly measuring the blood lead levels in venous blood.

References

  1. D'souza HS, Dsouza SA, Menezes G, Venkatesh T (2011). "Diagnosis, evaluation, and treatment of lead poisoning in general population". Indian J Clin Biochem. 26 (2): 197–201. doi:10.1007/s12291-011-0122-6. PMC 3107416. PMID 22468050.
  2. Herman DS, Geraldine M, Venkatesh T (2007). "Evaluation, diagnosis, and treatment of lead poisoning in a patient with occupational lead exposure: a case presentation". J Occup Med Toxicol. 2: 7. doi:10.1186/1745-6673-2-7. PMC 2000868. PMID 17718907.
  3. Peter F, Reynolds RG (1978). "Lead-erythrocyte protoporphyrin correlation in blood of exposed workers". Health Lab Sci. 15 (3): 144–9. PMID 701012.



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