Lady Windermere syndrome

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Lady Windermere syndrome
Lady windermere syndrome ct.JPG
CT scan of patient with right middle lobe aspiration and Mycobacterium avium infection consistent with Lady Windermere syndrome
ICD-10 A31.0
ICD-9 031.0
DiseasesDB 29182
eMedicine med/1532 
MeSH D015270

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Lady Windermere syndrome describes infection in the lungs due to Mycobacterium avium complex.[1] It is named after a character in Oscar Wilde's play Lady Windermere's Fan.[2]

Classification

Lady Windermere syndrome is a type of mycobacterial lung infection.[3]

Signs and symptoms

Patients with Lady Windermere syndrome experience chronic cough, shortness of breath, fatigue and other less specific symptoms.

Pathophysiology

Mycobacterium avium Complex (MAC) usually affects patients with abnormal lungs or bronchi. However, Jerome Reich and Richard Johnson describe a series of six patients with MAC infection of the right middle lobe or left lingula who did not have any predisposing lung disorders.

The right middle lobe and left lingula of the lungs are served by bronchi that are oriented downward when a person is in the upright position. As a result, these areas of the lung may be relatively more dependent upon vigorous voluntary expectoration (cough) for clearance of bacteria and secretions.

Since the six patients in their retrospective case series were older females, Reich and Johnson propose that patients without a vigorous cough may develop right middle lobe or left lingular infection with MAC. They propose that this syndrome be named Lady Windermere syndrome, after the character Lady Windermere in Oscar Wilde's play Lady Windermere's Fan.

Diagnosis

The diagnosis requires consistent symptoms with two additional signs:

Treatment

Lady Windermere syndrome is usually treated with rifampicin and ethambutol for at least two years. If symptoms do not improve, isoniazid or clarithromycin may be added.

Literary Reference

The original Chest article proposing the existence and pathophysiology of the Lady Windermere syndrome suggests that the character Lady Windermere in Oscar Wilde's Victorian-era play Lady Windermere's Fan is a good example of the fastidious behavior believed to cause the syndrome. The article states:

We offer the term, Lady Windermere's Syndrome, from the Victorian-era play, Lady Windermere's Fan, to convey the fastidious behavior hypothesized: "How do you do, Lord Darlington. No, I can't shake hands with you. My hands are all wet with the roses."

Victorian women presumably believed that "Ladies don't spit," and consequently might have been predisposed to develop lung infection.

Shortly after the Lady Windermere syndrome was proposed, a librarian wrote a letter to the editor of Chest[1] challenging the use of Lady Windermere as the eponymous ancestor of the proposed syndrome. In Lady Windermere's Fan, Lady Windermere is a vivacious young woman, married only 2 years, who never coughs or displays any other signs of illness. While her avoidance of shaking hands might be interpreted as "fastidiousness," two alternative explanations may be just as probable:

1) Lady Windermere actually is in the midst of arranging flowers and consequently cannot properly greet her guest:
[LADY WINDERMERE is at table R., arranging roses in a blue bowl.][2]
2) Lady Windermere wishes to discourage the flirtatious advances of her would-be suitor Lord Darlington and cites her wet hands as an excuse to keep him from touching her:
LADY WINDERMERE. Lord Darlington, you annoyed me last night at the Foreign Office. I am afraid you are going to annoy me again. . . .
LORD DARLINGTON. [Takes chair and goes across L.C.] I am quite miserable, Lady Windermere. You must tell me what I did. [Sits down at table L.]
LADY WINDERMERE. Well, you kept paying me elaborate compliments the whole evening.[3]

The OScholars [4] highlight the literary malapropism, but the medical community has adopted the term regardless, and peer-reviewed medical journals regularly mention the Lady Windermere syndrome.

References

  1. Reich, JM (Jun 1992). "Mycobacterium avium complex pulmonary disease presenting as an isolated lingular or middle lobe pattern. The Lady Windermere syndrome". Chest. American College of Chest Physicians. 101 (6): 1605–1609. Unknown parameter |coauthors= ignored (help)
  2. Wilde, Oscar (1940). The Importance of Being Earnest and Other Plays. Penguin. ISBN 0-14-048209-1.
  3. Campbell, I (Mar 2000). "Management of opportunist mycobacterial infections: Joint Tuberculosis Committee Guidelines 1999. Subcommittee of the Joint Tuberculosis Committee of the British Thoracic Society". Thorax. British Thoracic Society. 55 (3): 210–218.

Barker AF. Medical Progress: Bronchiectasis. N Engl J Med. 2 May 2002;346(18):1383-1393.

Morrissey BM, Harper RW. Bronchiectasis: Sex and gender considerations. Clin Chest Med. 2004;25:361-372.

Wickremasinghe M, Ozerovitch LJ, Davies G, Wodehouse T, Chadwick MV, Abdallah S, Shah P, Wilson R. Non-tuberculous mycobacteria in patients with bronchiectasis. Thorax. December 2005;60(12):1045-1051.



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