Lactose intolerance historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]

Overview

Lactose intolerance was first discovered by Hippocrate, the ancient Greek physician 2500 years ago. In 1906, Pimmer discovered lactase enzyme in the intestine of infant dogs, pigs, and rats. The association between the ethnicity and lactose intolerance was discovered in 1966 by Bayless and Rosensweig. In 1978, breath hydrogen test was used by Levitt to diagnose lactose intolerance.

Historical Perspective

Discovery

  • Lactose intolerance was first discovered by Hippocrate, the ancient Greek physician 2500 years ago.[1]
  • In 1906, Pimmer was the first scientist to discover lactase enzyme in the intestine of infant dogs, pigs, and rats. He also found that this enzyme decreased in the adult intestine of these animals.[1]
  • In 1959, Durand and Holzei et al decribed congenital lactase deficiency[1]
  • The association between the ethnicity and lactose intolerance was discovered in 1966 by Bayless and Rosensweig and in 1968 by Neale.
  • In the early 1970s, lactase-phlorizin hydrolase (LPH) gene mutations were first implicated in the pathogenesis of lactose intolerance.[2]
  • In 1978, breath hydrogen test was used by Levitt to diagnose lactose intolerance[3]


References

  1. 1.0 1.1 1.2 Neale G (1973). "The geographical incidence of lactase deficiency". Pathol Microbiol (Basel). 39 (3): 238–47. PMID 4718561. 
  2. Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Järvelä I (2002). "Identification of a variant associated with adult-type hypolactasia". Nat. Genet. 30 (2): 233–7. PMID 11788828. doi:10.1038/ng826. 
  3. Rana SV, Malik A (2014). "Hydrogen breath tests in gastrointestinal diseases". Indian J Clin Biochem. 29 (4): 398–405. PMC 4175689Freely accessible. PMID 25298621. doi:10.1007/s12291-014-0426-4. 

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