LPAR2

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Lysophosphatidic acid receptor 2 also known as LPA2 is a protein that in humans is encoded by the LPAR2 gene.[1][2][3] LPA2 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[4]

Function

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.[1]

Interactions

LPAR2 has been shown to interact with TRIP6.[5]

See also

References

  1. 1.0 1.1 "Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2".
  2. An S, Bleu T, Hallmark OG, Goetzl EJ (April 1998). "Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid". J. Biol. Chem. 273 (14): 7906–10. doi:10.1074/jbc.273.14.7906. PMID 9525886.
  3. An S, Bleu T, Zheng Y, Goetzl EJ (November 1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. PMID 9804623.
  4. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.
  5. Xu, Jun; Lai Yun-Ju; Lin Weei-Chin; Lin Fang-Tsyr (March 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. United States. 279 (11): 10459–68. doi:10.1074/jbc.M311891200. ISSN 0021-9258. PMC 3904432. PMID 14688263.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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