Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2gene.
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
↑Samaridis J, Colonna M (Apr 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur J Immunol. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID9079806.
↑Colonna, M; Samaridis J; Cella M; Angman L; Allen R L; O'Callaghan C A; Dunbar R; Ogg G S; Cerundolo V; Rolink A (Apr 1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". J. Immunol. UNITED STATES. 160 (7): 3096–100. ISSN0022-1767. PMID9531263.
Wagtmann N, Rojo S, Eichler E, et al. (1997). "A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors". Curr. Biol. 7 (8): 615–8. doi:10.1016/S0960-9822(06)00263-6. PMID9259559.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Colonna M, Samaridis J, Cella M, et al. (1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". J. Immunol. 160 (7): 3096–100. PMID9531263.
Borges L, Hsu ML, Fanger N, et al. (1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J. Immunol. 159 (11): 5192–6. PMID9548455.
Young NT, Canavez F, Uhrberg M, et al. (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics. 53 (4): 270–8. doi:10.1007/s002510100332. PMID11491530.
Chang CC, Ciubotariu R, Manavalan JS, et al. (2002). "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4". Nat. Immunol. 3 (3): 237–43. doi:10.1038/ni760. PMID11875462.
Papanikolaou NA, Vasilescu ER, Suciu-Foca N (2005). "Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4". Hum. Immunol. 65 (7): 700–5. doi:10.1016/j.humimm.2004.04.003. PMID15301858.