LILRB1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene.[1][2]

Function

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

See also

References

  1. Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML (Aug 1997). "A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules". Immunity. 7 (2): 273–82. doi:10.1016/S1074-7613(00)80529-4. PMID 9285411.
  2. Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, Angman L, Cella M, López-Botet M (Dec 1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". The Journal of Experimental Medicine. 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880.
  3. "Entrez Gene: LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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