LHRH receptor

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gonadotropin-releasing hormone receptor
Identifiers
SymbolGNRHR
Alt. symbolsGRHR
Entrez2798
HUGO4421
OMIM138850
RefSeqNM_001012763
UniProtP30968
Other data
LocusChr. 4 q21.2

The luteinizing hormone releasing hormone receptor is 60 kDa G protein-coupled receptor resides primarily in the pituitary and is responsible for eliciting the actions of LHRH after its release from the hypothalamus. Upon activation, the LHRHr stimulates tyrosine phosphatase and elicits the release of LH from the pituitary.

Evidence exists showing the presence of LHRH and its receptor in extrapituitary tissues as well as a role in progression of some cancers.



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