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Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Symbol(s) SEMA7A; CD108; CDw108; H-SEMA-K1; H-Sema K1; H-Sema-L; JMH; MGC126692; MGC126696; SEMAK1; SEMAL
External IDs OMIM: 607961 MGI1306826 Homologene2678
RNA expression pattern

File:PBB GE SEMA7A 210083 at tn.png

More reference expression data

Human Mouse
Entrez 8482 20361
Ensembl ENSG00000138623 ENSMUSG00000038264
Uniprot O75326 Q9QUR8
Refseq NM_003612 (mRNA)
NP_003603 (protein)
NM_011352 (mRNA)
NP_035482 (protein)
Location Chr 15: 72.49 - 72.51 Mb Chr 9: 57.74 - 57.76 Mb
Pubmed search [1] [2]

WikiDoc Resources for SEMA7A


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Most cited articles on SEMA7A

Review articles on SEMA7A

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Powerpoint slides on SEMA7A

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Evidence Based Medicine

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Definitions of SEMA7A

Patient Resources / Community

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Risk calculators and risk factors for SEMA7A

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Experimental / Informatics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]

Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (Cluster of Differentiation 108), is a human gene.[1]

SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.[supplied by OMIM][1]

See also


Further reading

  • Xu X, Ng S, Wu ZL; et al. (1998). "Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins.". J. Biol. Chem. 273 (35): 22428–34. PMID 9712866. 
  • Lange C, Liehr T, Goen M; et al. (1998). "New eukaryotic semaphorins with close homology to semaphorins of DNA viruses.". Genomics. 51 (3): 340–50. PMID 9721204. doi:10.1006/geno.1998.5256. 
  • Yamada A, Kubo K, Takeshita T; et al. (1999). "Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108.". J. Immunol. 162 (7): 4094–100. PMID 10201933. 
  • Angelisová P, Drbal K, Cerný J; et al. (1999). "Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules.". Immunobiology. 200 (2): 234–45. PMID 10416131. 
  • Tamagnone L, Artigiani S, Chen H; et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.". Cell. 99 (1): 71–80. PMID 10520995. 
  • Mine T, Harada K, Matsumoto T; et al. (2000). "CDw108 expression during T-cell development.". Tissue Antigens. 55 (5): 429–36. PMID 10885563. 
  • Holmes S, Downs AM, Fosberry A; et al. (2002). "Sema7A is a potent monocyte stimulator.". Scand. J. Immunol. 56 (3): 270–5. PMID 12193228. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMID 15489334. doi:10.1101/gr.2596504. 
  • Maurin JC, Delorme G, Machuca-Gayet I; et al. (2005). "Odontoblast expression of semaphorin 7A during innervation of human dentin.". Matrix Biol. 24 (3): 232–8. PMID 15907379. doi:10.1016/j.matbio.2005.03.005. 
  • Hu Y, Malone JP, Fagan AM; et al. (2006). "Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid.". Mol. Cell Proteomics. 4 (12): 2000–9. PMID 16199891. doi:10.1074/mcp.M500207-MCP200. 
  • Koh JM, Oh B, Lee JY; et al. (2006). "Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women.". J. Hum. Genet. 51 (2): 112–7. PMID 16372136. doi:10.1007/s10038-005-0331-z. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.