Isobutyryl-CoA mutase

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In enzymology, an isobutyryl-CoA mutase (EC is an enzyme that catalyzes the chemical reaction

2-methylpropanoyl-CoA butanoyl-CoA

Hence, this enzyme has one substrate, 2-methylpropanoyl-CoA, and one product, butanoyl-CoA.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is 2-methylpropanoyl-CoA CoA-carbonylmutase. Other names in common use include isobutyryl coenzyme A mutase, and butyryl-CoA:isobutyryl-CoA mutase. It has 2 cofactors: cobalt, and Cobamide coenzyme.


  • IUBMB entry for
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  • Willenbrock F and Robinson JA (1988). "The enzymic interconversion of isobutyryl and N-butyrylcarba(dethia)-coenzyme-A - a coenzyme-B12-dependent carbon skeleton rearrangement". Angew. Chem. Int. Ed. Engl. 27: 1089&ndash, 1091.

External links

Gene Ontology (GO) codes