Ipodate sodium

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Ipodate sodium
Ipodate.png
Clinical data
Routes of
administration
oral, Intravenous
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
ChEMBL
E number{{#property:P628}}
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Chemical and physical data
FormulaC12H12I3N2NaO2
Molar mass619.93906 g/mol
3D model (JSmol)
Melting point168-169 °C (-104.2 °F)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Ipodate sodium (sodium iopodate) is an iodine-containing radiopaque contrast media used for X-rays. The drug is given orally and the resulting contrast allows for easy resolution of the bile duct and gall bladder. The drug goes by the trade name Oragrafin or Gastrografin.[1]

Other uses

Although not FDA approved, ipodate sodium has been used to treat Graves' disease and thyroid storm, an extreme form of hyperthyroidism.

Graves' disease

Long-term treatment of Graves' disease with ipodate sodium (500 mg, daily) given by mouth reduced levels of T3 and T4 in the patients.[2] This was done with minimal side effects, indicating possible clinical usefulness. Iodine uptake was also noted to return to normal within seven days, indicating control with ipodate with rapid follow up treatment with 131I is feasible.

Thyroid Storm

In emergency situations, ipodate can be administered for thyroid storm. As the ipodate is metabolized, it releases iodine into circulation, helping bring the T3 and T4 levels back down. Ipodate also inhibits the conversion of T4 to T3 (which is more potent). It is not considered a first-line approach, as potassium iodide and beta blockers have less potential for side-effects. Ipodate sodium lacks FDA approval for this use.

References

  1. http://www.drugs.com/cons/cholecystographic-agent.html
  2. DC Shen, SY Wu, IJ Chopra, HW Huang, LR Shian, TY Bian, CY Jeng and DH Solomon (1985). "Long term treatment of Graves' hyperthyroidism with sodium ipodate". Journal of Clinical Endocrinology & Metabolism. 61 (4): 723–727. doi:10.1210/jcem-61-4-723. PMID 3928675.

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