Intervillous space

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Intervillous space
Primary chorionic villi. Diagrammatic.
Secondary chorionic villi. Diagrammatic.
Gray's subject #12 59
Days 24
Dorlands/Elsevier s_16/12745451

As a brief introduction, "inter" means between, and "villous" means vessels, so the intervillous space is the "space between the vessels" of the mother and the embryo.

The trophoblast, which is a collection of cells that invades the maternal endometrium to gain access to nutrition for the fetus, proliferates rapidly and forms a network of branching processes which cover the entire embryo and invade and destroy the maternal tissues. With this physiologic destructive process, the maternal blood vessels of the endometrium are opened, with the result that the spaces in the trophoblastic network are filled with maternal blood; these spaces communicate freely with one another and become greatly distended and form the intervillous space from which the fetus gains nutrition.

Maternal arteries and veins directly enter the intervillous space after 8 weeks gestation, and the intervillous space will contain about a unit of blood (400-500 mL). Much of this blood is returned to the mother with normal uterine contractions; thus, when a woman has a cesarean section, she is liable to lose more blood than a woman who has a vaginal delivery, as the blood from the intervillous space is not pushed back toward her body during such a delivery.


File:Intervillous space.JPG
Intervillous space.


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This article was originally based on an entry from a public domain edition of Gray's Anatomy. As such, some of the information contained herein may be outdated. Please edit the article if this is the case, and feel free to remove this notice when it is no longer relevant.


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