Interleukin 37

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Interleukin-1 family member 7 is a protein that in humans is encoded by the IL1F7 gene.[1][2][3][4]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.[4]

See also

References

  1. Smith DE, Renshaw BR, Ketchem RR, Kubin M, Garka KE, Sims JE (Feb 2000). "Four new members expand the interleukin-1 superfamily". J Biol Chem. 275 (2): 1169–75. doi:10.1074/jbc.275.2.1169. PMID 10625660.
  2. Mulero JJ, Pace AM, Nelken ST, Loeb DB, Correa TR, Drmanac R, Ford JE (Nov 1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochem Biophys Res Commun. 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743.
  3. Gao W, Kumar S, Lotze MT, Hanning C, Robbins PD, Gambotto A (Dec 2002). "Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity". J Immunol. 170 (1): 107–13. doi:10.4049/jimmunol.170.1.107. PMID 12496389.
  4. 4.0 4.1 "Entrez Gene: IL37 interleukin 37".

Further reading



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