Interleukin 14

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Interleukin 14
Identifiers
SymbolTXNLA
Alt. symbolsHMW-BCGF, IL14
Entrez3599
HUGO5976
OMIM608676
RefSeqNP_787048
UniProtL15344
Other data
LocusChr. 1 p34.3

Interleukin-14 (IL-14) is a cytokine that is also called High molecular weight B-cell growth factor (HMW-BCGF) that controls the growth and proliferation of both normal and cancerous B cells.[1] This molecule was also recently designated taxilin.[2] IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells.

Two distinct transcripts are produced from opposite strands of the il14 gene that are called IL-14α and IL-14β.[3] The il14 locus is near the gene for LCK on chromosome 1 in humans.

References

  1. Ambrus JL et al., Identification of a cDNA for a human high-molecular-weight B-cell growth factor., 1993, Proceedings of the National Academy of Sciences USA, Volume 90, pages 6330-4.
  2. Nogami,S et al., Taxilin; a novel syntaxin-binding protein that is involved in Ca2+- dependent exocytosis in neuroendocrine cells. Genes Cells, 2003, Volume 8, pages 17-28
  3. Shen, L. et al., Development of Autoimmunity in IL-14-Transgenic Mice. The Journal of Immunology, 2006, Volume 177, pages 5676-5686.



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