Interleukin-27 receptor

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interleukin 27 receptor, alpha
Identifiers
SymbolIL27RA
Alt. symbolsWSX-1, TCCR, CRL1, WSX1, zcytor1, IL-27R
Entrez9466
HUGO17290
OMIM605350
RefSeqNM_004843
UniProtQ6UWB1
Other data
LocusChr. 19 p13.11
interleukin 6 signal transducer (gp130, oncostatin M receptor)
Identifiers
SymbolIL6ST
Alt. symbolsGP130, CD130
Entrez3572
HUGO6021
OMIM600694
RefSeqNM_002184
UniProtP40189
Other data
LocusChr. 5 q11

The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit[1][2] and glycoprotein 130.[3]

IL27RA essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation.[4]

References

  1. Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T, Whitmore TE, O'Hara PJ, Foster DF (1998). "Cloning and characterization of a novel class I cytokine receptor". Biochem. Biophys. Res. Commun. 246 (1): 82–90. doi:10.1006/bbrc.1998.8576. PMID 9600072.
  2. Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ (2000). "Development of Th1-type immune responses requires the type I cytokine receptor TCCR". Nature. 407 (6806): 916–20. doi:10.1038/35038103. PMID 11057672.
  3. Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA (February 2004). "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27". Journal of Immunology. 172 (4): 2225–31. doi:10.4049/jimmunol.172.4.2225. PMID 14764690.
  4. Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H (May 2003). "Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment". J. Immunol. 170 (10): 4886–90. doi:10.4049/jimmunol.170.10.4886. PMID 12734330.

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