Interleukin-18 receptor

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interleukin 18 receptor 1
Identifiers
SymbolIL18R1
Alt. symbolsIL1RRP, IL-1Rrp, CD218a
Entrez8809
HUGO5988
OMIM604494
RefSeqNM_003855
UniProtQ13478
Other data
LocusChr. 2 q12
interleukin 18 receptor accessory protein
Identifiers
SymbolIL18RAP
Alt. symbolsAcPL, CD218b
Entrez8807
HUGO5989
OMIM604509
RefSeqNM_003853
UniProtO95256
Other data
LocusChr. 2 p24.3-24.1

The interleukin-18 receptor (IL-18R) is an interleukin receptor of the immunoglobulin superfamily.[1][2] IL-18R is a heteromeric complex of alpha- and beta-chains encoded by the genes IL18R1 and IL18RAP respectively.

Endometrial IL-18 receptor mRNA and the ratio of IL-18 binding protein to interleukin 18 are significantly increased in adenomyosis patients in comparison to normal people, indicating a role in its pathogenesis.[3]

References

  1. Sergi B, Penttila I (2004). "Interleukin 18 receptor". J. Biol. Regul. Homeost. Agents. 18 (1): 55–61. PMID 15323361.
  2. Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, Ghayur T (2003). "IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction". J. Immunol. 170 (11): 5571–7. doi:10.4049/jimmunol.170.11.5571. PMID 12759435.
  3. Huang, H.; Yu, H.; Chan, S.; Lee, C.; Wang, H.; Soong, Y. (2010). "Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients". Fertility and Sterility. 94 (1): 33–39. doi:10.1016/j.fertnstert.2009.01.132. PMID 19394601.

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