Interleukin-10 receptor

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interleukin 10 receptor, alpha
Identifiers
SymbolIL10RA
Alt. symbolsIL10R
Entrez3587
HUGO5964
OMIM146933
RefSeqNM_001558
UniProtQ13651
Other data
LocusChr. 11 q23
interleukin 10 receptor, beta
Identifiers
SymbolIL10RB
Alt. symbolsCRFB4, D21S58, D21S66
Entrez3588
HUGO5965
OMIM123889
RefSeqNM_000628
UniProtQ08334
Other data
LocusChr. 21 q22.1-22.2

Interleukin-10 receptor is a type II cytokine receptor. The receptor is tetrameric, composed of 2α[1] and 2β[2] subunits. The α subunit is expressed on haematopoietic cells (such as T, B, NK, mast, and dendritic cells) whilst the β subunit is expressed ubiquitously.

References

  1. Liu Y, Wei SH, Ho AS, de Waal Malefyt R, Moore KW (1994). "Expression cloning and characterization of a human IL-10 receptor". J. Immunol. 152 (4): 1821–9. PMID 8120391.
  2. Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Pestka S (1997). "Identification and functional characterization of a second chain of the interleukin-10 receptor complex". EMBO J. 16 (19): 5894–903. doi:10.1093/emboj/16.19.5894. PMC 1170220. PMID 9312047.

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