Integrin alpha 9

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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



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Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene.[1][2][3] Cytogenetic location: 3p22.2 [4]


This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for tenascin-C, VCAM1 and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers.[3]


The α9 subunit forms a heterodimeric complex with a β1 subunit to form the α9β1 integrin. This integrin participates in cell adhesion with various ligands in the extracellular matrix (ECM), including extra domain A (EDA) fibronectin, tenascin-C, ADAMs, EMELIN1, osteopontin, and VEGF.[5] α9β1 binding is independent of the RGD peptide sequence.


  1. Palmer EL, Rüegg C, Ferrando R, Pytela R, Sheppard D (Jan 1994). "Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle". J Cell Biol. 123 (5): 1289–97. doi:10.1083/jcb.123.5.1289. PMC 2119880. PMID 8245132.
  2. Hibi K, Yamakawa K, Ueda R, Horio Y, Murata Y, Tamari M, Uchida K, Takahashi T, Nakamura Y, Takahashi T (Feb 1994). "Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer". Oncogene. 9 (2): 611–9. PMID 8290272.
  3. 3.0 3.1 "Entrez Gene: ITGA9 integrin, alpha 9".
  4. Sulimova G, Kutsenko A, Rakhmanaliev E, Udina I, Kompaniytsev A, Protopopov A, Moisjak E, Klimov E, Muravenko O, Zelenin A, Braga E, Kashuba V, Zabarovsky E, Kisselev L (2002). "Human chromosome 3: integration of 60 NotI clones into a physical and gene map". Cytogenetic and Genome Research. 98: 177–183. doi:10.1159/000069814.
  5. Høye AM, Couchman JR, Wewer UM, Fukami K, Yoneda A (May 2012). "The newcomer in the integrin family: integrin α9 in biology and cancer". Advances in biological regulation. 52 (2): 326–39. doi:10.1016/j.jbior.2012.03.004. PMID 22781746.

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