Integrin, beta 6

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
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RefSeq (mRNA)

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RefSeq (protein)

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Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene.[1][2][3]


Clinical effects

Mutations in ITGB6 cause amelogenesis imperfecta .[4]

Interactions

Integrin, beta 6 has been shown to interact with FHL2.[5]

References

  1. Krissansen GW, Yuan Q, Jenkins D, Jiang WM, Rooke L, Spurr NK, Eccles M, Leung E, Watson JD (February 1992). "Chromosomal locations of the genes coding for the integrin beta 6 and beta 7 subunits". Immunogenetics. 35 (1): 58–61. doi:10.1007/bf00216629. PMID 1729173.
  2. Weinacker A, Chen A, Agrez M, Cone RI, Nishimura S, Wayner E, Pytela R, Sheppard D (April 1994). "Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor". J Biol Chem. 269 (9): 6940–8. PMID 8120056.
  3. "Entrez Gene: ITGB6 integrin, beta 6".
  4. Wang, S. K.; Choi, M; Richardson, A. S.; Reid, B. M.; Lin, B. P.; Wang, S. J.; Kim, J. W.; Simmer, J. P.; Hu, J. C. (2014). "ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta". Human Molecular Genetics. 23 (8): 2157–63. doi:10.1093/hmg/ddt611. PMC 3959820. PMID 24305999.
  5. Wixler, V; Geerts D; Laplantine E; Westhoff D; Smyth N; Aumailley M; Sonnenberg A; Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. UNITED STATES. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324.

Further reading

External links



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