Integrin, beta 5

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.[1][2]


Interactions

Integrin, beta 5 has been shown to interact with PTK2,[3] Annexin A5[4] and PAK4.[5]

Clinical significance

Research

Elevated levels of ITGB5 have been found in patients suffering from autosomal dominant osteopetrosis type II, a rare disease of bones.[6]

References

  1. McLean JW, Vestal DJ, Cheresh DA, Bodary SC (Nov 1990). "cDNA sequence of the human integrin beta 5 subunit". J Biol Chem. 265 (28): 17126–31. PMID 2211615.
  2. "Entrez Gene: ITGB5 integrin, beta 5".
  3. Eliceiri, Brian P; Puente Xose S; Hood John D; Stupack Dwayne G; Schlaepfer David D; Huang Xiaozhu Z; Sheppard Dean; Cheresh David A (Apr 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. United States. 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263. PMID 11927607.
  4. Cardó-Vila, Marina; Arap Wadih; Pasqualini Renata (May 2003). "Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. Cell. United States. 11 (5): 1151–62. doi:10.1016/S1097-2765(03)00138-2. ISSN 1097-2765. PMID 12769841.
  5. Zhang, Hongquan; Li Zhilun; Viklund Eva-Karin; Strömblad Staffan (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". J. Cell Biol. United States. 158 (7): 1287–97. doi:10.1083/jcb.200207008. ISSN 0021-9525. PMC 2173231. PMID 12356872.
  6. Coudert, AE (Mar 2014). "Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology". Lab Invest. 94 (3): 275–285. doi:10.1038/labinvest.2013.140. PMID 24336069.

Further reading

External links



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