Insulinoma causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]

Insulinoma Microchapters

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Overview

The cause of insulinoma has not been identified. To review risk factors for the development of insulinoma, click here.

Causes

There are no established causes of insulinoma but there is an association with MEN 1 syndrome and rarely with Von Hippel-Lindau disease, Neurofibromatosis-1 and Tuberous sclerosis. [1][2][3]

References

  1. Service FJ, McMahon MM, O'Brien PC, Ballard DJ (1991). "Functioning insulinoma--incidence, recurrence, and long-term survival of patients: a 60-year study". Mayo Clin Proc. 66 (7): 711–9. PMID 1677058.
  2. Jensen RT, Berna MJ, Bingham DB, Norton JA (2008). "Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversies". Cancer. 113 (7 Suppl): 1807–43. doi:10.1002/cncr.23648. PMC 2574000. PMID 18798544.
  3. Beisang D, Forlenza GP, Luquette M, Sarafoglou K (2017). "Sporadic Insulinoma Presenting as Early Morning Night Terrors". Pediatrics. doi:10.1542/peds.2016-2007. PMID 28562256.


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