Jump to: navigation, search
inhibin, alpha
Symbol INHA
Entrez 3623
HUGO 6065
OMIM 147380
RefSeq NM_002191
UniProt P05111
Other data
Locus Chr. 2 q33-qter
inhibin, beta A (activin A, activin AB alpha polypeptide)
Symbol INHBA
Entrez 3624
HUGO 6066
OMIM 147290
RefSeq NM_002192
UniProt P08476
Other data
Locus Chr. 7 p15-p13
inhibin, beta B (activin AB beta polypeptide)
Symbol INHBB
Entrez 3625
HUGO 6067
OMIM 147390
RefSeq NM_002193
UniProt P09529
Other data
Locus Chr. 2 cen-q13

WikiDoc Resources for Inhibin


Most recent articles on Inhibin

Most cited articles on Inhibin

Review articles on Inhibin

Articles on Inhibin in N Eng J Med, Lancet, BMJ


Powerpoint slides on Inhibin

Images of Inhibin

Photos of Inhibin

Podcasts & MP3s on Inhibin

Videos on Inhibin

Evidence Based Medicine

Cochrane Collaboration on Inhibin

Bandolier on Inhibin

TRIP on Inhibin

Clinical Trials

Ongoing Trials on Inhibin at Clinical

Trial results on Inhibin

Clinical Trials on Inhibin at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Inhibin

NICE Guidance on Inhibin


FDA on Inhibin

CDC on Inhibin


Books on Inhibin


Inhibin in the news

Be alerted to news on Inhibin

News trends on Inhibin


Blogs on Inhibin


Definitions of Inhibin

Patient Resources / Community

Patient resources on Inhibin

Discussion groups on Inhibin

Patient Handouts on Inhibin

Directions to Hospitals Treating Inhibin

Risk calculators and risk factors for Inhibin

Healthcare Provider Resources

Symptoms of Inhibin

Causes & Risk Factors for Inhibin

Diagnostic studies for Inhibin

Treatment of Inhibin

Continuing Medical Education (CME)

CME Programs on Inhibin


Inhibin en Espanol

Inhibin en Francais


Inhibin in the Marketplace

Patents on Inhibin

Experimental / Informatics

List of terms related to Inhibin

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753


Inhibin is a peptide that is an inhibitor of FSH synthesis and secretion,[1] and participates in the regulation of the menstrual cycle.


Inhibin contains an alpha and beta subunit linked by disulfide bonds. Two forms of inhibin differ in their beta subunits (A or B), while their alpha subunits are identical.

Inhibin belongs to the transforming growth factor-β (TGF-β) superfamily.


In women

In women, FSH stimulates the secretion of inhibin from the granulosa cells of the ovarian follicles in ovary. In turn, inhibin suppresses FSH.

Inhibin secretion is diminished by GnRH, and enhanced by insulin-like growth factor-1 (IGF-1).

Inhibin is produced in the gonads, pituitary gland, placenta and other organs.

In men

In men, it is a hormone that inhibits FSH production.

It is secreted from the Sertoli cells,[2] located in the seminiferous tubule inside the testes.


Activin is a related peptide that counteracts inhibin.

Clinical significance

Quantification of inhibin A is part of the prenatal quad screen that can be administered during pregnancy at a gestational age of 16-18 weeks. An elevated inhibin A (along with an increased beta-hCG, decreased AFP, and a decreased estriol) is [3] suggestive of the presence of a fetus with Down's syndrome. As a screening test, abnormal quad screen test results need to be followed up with more definitive tests.

It also has been used as a marker for ovarian cancer.[4][5]


  1. van Zonneveld P, Scheffer G, Broekmans F, Blankenstein M, de Jong F, Looman C, Habbema J, te Velde E (2003). "Do cycle disturbances explain the age-related decline of female fertility? Cycle characteristics of women aged over 40 years compared with a reference population of young women". Hum Reprod. 18 (3): 495–501. PMID 12615813. 
  2. Skinner M, McLachlan R, Bremner W (1989). "Stimulation of Sertoli cell inhibin secretion by the testicular paracrine factor PModS". Mol Cell Endocrinol. 66 (2): 239–49. PMID 2515083. 
  3. Aitken D, Wallace E, Crossley J, Swanston I, van Pareren Y, van Maarle M, Groome N, Macri J, Connor J (1996). "Dimeric inhibin A as a marker for Down's syndrome in early pregnancy". N Engl J Med. 334 (19): 1231–6. PMID 8606718. 
  4. Robertson D, Pruysers E, Jobling T. "Inhibin as a diagnostic marker for ovarian cancer". Cancer Lett. PMID 17320281. 
  5. Robertson D, Pruysers E, Burger H, Jobling T, McNeilage J, Healy D (2004). "Inhibins and ovarian cancer". Mol Cell Endocrinol. 225 (1-2): 65–71. PMID 15451569.