Indoprofen

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Indoprofen
File:Indoprofen.svg
Clinical data
Routes of
administration
Oral
ATC code
Legal status
Legal status
  • Withdrawn
Pharmacokinetic data
BioavailabilityHigh (rapid and complete absorption)
MetabolismGlucuronidation
Elimination half-life2.3 hours
ExcretionRenal
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC17H15NO3
Molar mass281.306 g/mol

Indoprofen is a non-steroidal anti-inflammatory drug. It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.[1]

A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies.[1][2]

References

  1. 1.0 1.1 Frazin, Natalie (March 9 2005). "Pain Reliever May Provide Clues for Treating Spinal Muscular Atrophy". United States National Institute of Neurological Disorders and Stroke. Retrieved 2007-10-06. Check date values in: |date= (help)
  2. Lunn MR, Root DE, Martino AM; et al. (2004). "Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism". Chem Biol. 11 (11): 1489–93. doi:10.1016/j.chembiol.2004.08.024. PMID 15555999.



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