ITGA2B

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene.

ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[1]

Interactions

ITGA2B has been shown to interact with AUP1[2] and CLNS1A.[3]

See also

References

  1. "Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)".
  2. Kato, Atsushi; Kawamata Norihiko; Tamayose Kenji; Egashira Motoki; Miura Rika; Fujimura Tsutomu; Murayama Kimie; Oshimi Kazuo (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J. Biol. Chem. United States. 277 (32): 28934–41. doi:10.1074/jbc.M204340200. ISSN 0021-9258. PMID 12042322.
  3. Larkin, Deirdre; Murphy Derek; Reilly Dermot F; Cahill Martha; Sattler Ellen; Harriott Pat; Cahill Dolores J; Moran Niamh (Jun 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. United States. 279 (26): 27286–93. doi:10.1074/jbc.M402159200. ISSN 0021-9258. PMID 15075326.

Further reading

External links



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