Hydroxyacid-oxoacid transhydrogenase

Jump to: navigation, search

In enzymology, a hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24) is an enzyme that catalyzes the chemical reaction

(S)-3-hydroxybutanoate + 2-oxoglutarate acetoacetate + (R)-2-hydroxyglutarate

Thus, the two substrates of this enzyme are (S)-3-hydroxybutanoate and 2-oxoglutarate, whereas its two products are acetoacetate and (R)-2-hydroxyglutarate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase. This enzyme is also called transhydrogenase, hydroxy acid-oxo acid.

References

  • IUBMB entry for 1.1.99.24
  • BRENDA references for 1.1.99.24 (Recommended.)
  • PubMed references for 1.1.99.24
  • PubMed Central references for 1.1.99.24
  • Google Scholar references for 1.1.99.24
  • Kaufman EE, Nelson T, Fales HM, Levin DM (1988). "Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria". J. Biol. Chem. 263: 16872&ndash, 9. PMID 3182820.

External links

The CAS registry number for this enzyme class is 117698-31-4.

Gene Ontology (GO) codes

Template:1.1-enzyme-stub


Linked-in.jpg