Holocytochrome-c synthase

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In enzymology, a holocytochrome-c synthase (EC is an enzyme that catalyzes the chemical reaction

holocytochrome c apocytochrome c + heme

Hence, this enzyme has one substrate, holocytochrome c, and two products, apocytochrome c and heme.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is holocytochrome-c apocytochrome-c-lyase (heme-forming). Other names in common use include cytochrome c heme-lyase, holocytochrome c synthetase, and holocytochrome-c apocytochrome-c-lyase. This enzyme participates in porphyrin and chlorophyll metabolism.


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  • Dumont ME, Ernst JF, Hampsey DM, Sherman F (1987). "Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae". EMBO. J. 6: 235&ndash, 41. PMID 3034577.

External links

The CAS registry number for this enzyme class is 75139-03-6.

Gene Ontology (GO) codes