Histone methyltransferase

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euchromatic histone-lysine N-methyltransferase 1
Identifiers
SymbolEHMT1
Entrez79813
HUGO24650
OMIM607001
RefSeqNM_024757
UniProtQ9H9B1
Other data
EC number2.1.1.43
LocusChr. 9 [1]

Histone methyltransferases (HMT) are enzymes, histone-lysine N-methyltransferase and histone-arginine N-methyltransferase, which catalyze the transfer of one to three methyl groups from the cofactor S-Adenosyl methionine to lysine and arginine residues of histone proteins. These proteins often contain an SET (Su(var)3-9, Enhancer of Zeste, Trithorax) domain, however the recently discovered HMT Dot1 lacks the characteristic SET domain.

Histone methylation serves in epigenetic gene regulation. Methylated histones bind DNA more tightly, which inhibits transcription.

See also

Methylated histones can either repress or activate transcription as different experimental findings suggest.

External links


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