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WikiDoc Resources for Hemoglobinopathy


Most recent articles on Hemoglobinopathy

Most cited articles on Hemoglobinopathy

Review articles on Hemoglobinopathy

Articles on Hemoglobinopathy in N Eng J Med, Lancet, BMJ


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Evidence Based Medicine

Cochrane Collaboration on Hemoglobinopathy

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Clinical Trials

Ongoing Trials on Hemoglobinopathy at Clinical Trials.gov

Trial results on Hemoglobinopathy

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Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Hemoglobinopathy

NICE Guidance on Hemoglobinopathy


FDA on Hemoglobinopathy

CDC on Hemoglobinopathy


Books on Hemoglobinopathy


Hemoglobinopathy in the news

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Definitions of Hemoglobinopathy

Patient Resources / Community

Patient resources on Hemoglobinopathy

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Directions to Hospitals Treating Hemoglobinopathy

Risk calculators and risk factors for Hemoglobinopathy

Healthcare Provider Resources

Symptoms of Hemoglobinopathy

Causes & Risk Factors for Hemoglobinopathy

Diagnostic studies for Hemoglobinopathy

Treatment of Hemoglobinopathy

Continuing Medical Education (CME)

CME Programs on Hemoglobinopathy


Hemoglobinopathy en Espanol

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Hemoglobinopathy in the Marketplace

Patents on Hemoglobinopathy

Experimental / Informatics

List of terms related to Hemoglobinopathy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Hemoglobinopathy is a kind of genetic defect that results in abnormal structure of one of the globin chains of the hemoglobin molecule. Most common hemoglobinopathies include sickle-cell disease.


Most clinically significant hemoglobinopathies cause mild to acute anemia, in rare cases hemolytic anemia. Symptoms vary for the different diseases: in sickle cell disease the red blood cells tend to assume a different shape under anaerobic conditions, leading to organ damage and circulatory problems, while in thalassemia there is ineffective production of red blood cells (erythropoiesis).

Migration patterns

Migration patterns (Alkaline Electrophoresis)

In general on alkaline electrophoresis in order of increasing mobility are hemoglobins A2, E=O=C, G=D=S=Lepore, F, A, K, J, Bart's, N, I, and H.

In general a sickling test (sodium bisulfite) is performed on abnormal hemoglobins migrating in the S location to see if the red cells precipitate in solution.

Migration patterns (Acid Electrophoresis)

In general on acid electrophoresis in order of increasing mobility are hemoglobins F, A=D=G=E=O=Lepore, S, and C.

This is how abnormal Hgb variants are isolated and identified using these two methods. For example a Hgb G-Philadelphia would migrate with S on alkaline electrophoresis and would migrate with A on acid electrophoresis, respectively.

Common variants

  • Hb S
  • Hb C
  • Hb E
  • Hb D-Punjab
  • Hb O-Arab
  • Hb G-Philadelphia
  • Hb Hasharon
  • Hb Korle-Bu
  • Hb Lepore
  • Hb M

Hemoglobinopathy and evolution

Some hemoglobinopathies (and also related diseases like glucose-6-phosphate dehydrogenase deficiency) seem to have given an evolutionary benefit, especially to heterozygotes, in areas where malaria is endemic. Malaria parasites live inside red blood cells, but subtly disturb normal cellular function. In patients predisposed for rapid clearance of red blood cells, this may lead to early destruction of cells infected with the parasite and increased chance of survival for the carrier of the trait.de:Hämoglobinopathie nl:Hemoglobinopathie