Hemochromatosis physical examination
Hemochromatosis physical examination On the Web
American Roentgen Ray Society Images of Hemochromatosis physical examination
Physical examination of hemochromatosis disease depends on the involved organ are: fatigue in heart failure, erectile dysfunction and hypogonadism in gonadal involvements, amenorrhea in pitutary, arthritis in joints involvement.
- Erectile dysfunction and hypogonadism
- Congestive heart failure, arrhythmias or pericarditis
- Dyskinesias, including Parkinsonian symptoms
- Dysfunction of certain endocrine organs:
- A darkish color to the skin (see pigmentation, hence its name Diabete bronze )
Males are usually diagnosed after their forties, and women about a decade later, owing to regular iron loss by menstruation (which ceases in menopause). Cases of iron overload have been found in young children as well.
Loss of motor control
|Loss of two point discrimination
Hyporeflaxia decreased power
|Axonal sensory motor polyneuropathy|
|CNS||Abnormal gait||Dyskinesias(Parkinsonian syndrome Multiple sclerosis)
|Deposition of iron in basal ganglia|
|Endocrine||Pituitary gland||Menstrual abnormality
Loss of libido
Loss of body hair
|Deposition of iron in pituitary gland|
|Thyroid gland||Fatigue||Signs of hypothyroidism||Deposition of iron in thyroid gland|
|Pancreas||Polyuria polydipsia polyphagia||Polyuria, polydipsia, polyphagia||Deposition of iron in pancreas|
|Adrenal gland||Fatigue||Polyuria, Hypotension||Deposition of iron in adrenal gland|
|Dermatological||Skin||Cutaneous hyperpigmentation||Sun exposed affected mostly with tan of melanin grey
Porphyria cutanea tarda
|Iron damage skin, melanin hyperactivity responds thus color of melanin|
|Joints||Metacarpophalangeal (especially 2nd and 3rd MCP joints)||Pain
Stiffness improve with rest
|Deposition of iron in articular cartilage
Heart failure palpitation Hypertension
|Deposition of iron in cardiac tissue and blood vessels|
Cutaneous stigmata of chronic liver disease
|Deposition of iron in liver|
|Gallbladder||Right upper abdominal pain||Tender hepatomegaly||Multiple blood transfusion leading to hemochromatosis|
- Jones H, Hedley-Whyte E (1983). "Idiopathic hemochromatosis (IHC): dementia and ataxia as presenting signs". Neurology. 33 (11): 1479–83. PMID 6685241.
- Costello D, Walsh S, Harrington H, Walsh C (2004). "Concurrent hereditary haemochromatosis and idiopathic Parkinson's disease: a case report series". J Neurol Neurosurg Psychiatry. 75 (4): 631–3. PMID 15026513.
- Nielsen J, Jensen L, Krabbe K (1995). "Hereditary haemochromatosis: a case of iron accumulation in the basal ganglia associated with a parkinsonian syndrome". J Neurol Neurosurg Psychiatry. 59 (3): 318–21. PMID 7673967.