Helicobacter pylori infection historical perspective

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Helicobacter pylori infection Microchapters


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yamuna Kondapally, M.B.B.S[2]


The association between helicobacter pylori and peptic ulcers was made by Barry Marshall and Robin Warren in the year 1984 for which they were awarded the Nobel Prize in 2005 in physiology or medicine.

Historical Perspective

  • In 1999, the MACH 2 study states that culture is an accurate way to diagnose H.pylori infection.[9]
  • The association between H.pylori infection and gastric cancer is found in 2001.[7]
  • In 2002, The Maastricht 2 Consensus Report states that a 'test-to-treat' approach is recommended in adult patients under the age of 45 years.[10]
  • In 2005, Barry Marshall and Robin Warren won Nobel prize in physiology or medicine for their "discovery of bacterium Helicobacter pylori and and its role in gastritis and peptic ulcer disease".[4]


  1. Fock KM, Graham DY, Malfertheiner P (2013). "Helicobacter pylori research: historical insights and future directions". Nat Rev Gastroenterol Hepatol. 10 (8): 495–500. doi:10.1038/nrgastro.2013.96. PMC 3973742. PMID 23752823.
  2. Kusters JG, van Vliet AH, Kuipers EJ (2006). "Pathogenesis of Helicobacter pylori infection". Clin Microbiol Rev. 19 (3): 449–90. doi:10.1128/CMR.00054-05. PMC 1539101. PMID 16847081.
  3. "Unidentified curved bacilli on gastric epithelium in active chronic gastritis". Lancet. 1 (8336): 1273–5. 1983. PMID 6134060.
  4. 4.0 4.1 Marshall BJ, Armstrong JA, McGechie DB, Glancy RJ (1985). "Attempt to fulfil Koch's postulates for pyloric Campylobacter". Med J Aust. 142 (8): 436–9. PMID 3982345.
  5. "NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease". JAMA. 272 (1): 65–9. 1994. PMID 8007082.
  6. Tanida N, Sakagami T, Sawada Y, Shimoyama T (1997). "[Critical review on the WHO/IARC report regarding carcinogenicity of Helicobacter pylori]". Nippon Rinsho (in Japanese). 55 (4): 995–1002. PMID 9103907.
  7. 7.0 7.1 Uemura, Naomi; Okamoto, Shiro; Yamamoto, Soichiro; Matsumura, Nobutoshi; Yamaguchi, Shuji; Yamakido, Michio; Taniyama, Kiyomi; Sasaki, Naomi; Schlemper, Ronald J. (2001). "Helicobacter pyloriInfection and the Development of Gastric Cancer". New England Journal of Medicine. 345 (11): 784–789. doi:10.1056/NEJMoa001999. ISSN 0028-4793.
  8. Hopkins RJ (1997). "Current FDA-approved treatments for Helicobacter pylori and the FDA approval process". Gastroenterology. 113 (6 Suppl): S126–30. PMID 9394774.
  9. McMahon MJ, Pickford IR (1979). "Biochemical prediction of gallstones early in an attack of acute pancreatitis". Lancet. 2 (8142): 541–3. PMID 89554.
  10. Malfertheiner P, Mégraud F, O'Morain C, Hungin AP, Jones R, Axon A, Graham DY, Tytgat G (2002). "Current concepts in the management of Helicobacter pylori infection--the Maastricht 2-2000 Consensus Report". Aliment. Pharmacol. Ther. 16 (2): 167–80. PMID 11860399.