HLA-DOA

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Identifiers
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External IDsGeneCards: [1]
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SpeciesHumanMouse
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HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.[1][2]

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.[2]

References

  1. Young JA, Trowsdale J (Aug 1990). "The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript". Immunogenetics. 31 (5–6): 386–8. doi:10.1007/BF02115015. PMID 2370084.
  2. 2.0 2.1 "Entrez Gene: HLA-DOA major histocompatibility complex, class II, DO alpha".

Further reading



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